Abstract
We have carried out the analysis of antymicobacterial activity of PYATd10 diazinon derivative and dapsone. The capability of PYATd10 compound and dapsone drug to suppress the growth of M.lufu culture was studied by the method of serial dilutions. Visual evaluation of inoculations in medium Shkolnikova showed that there was no growth of mycobacteria with PYATd10 concentration 128 μg/ml, while minimum suppressing concentration of dapsone were equal to 32 μg/ml. Examining smears, colored according to Murohashi, under the influence of PYATd10 excipient and dapsone drug in the same concentrations, we have revealed the decrease of mycobacterial living forms content. A share of inviable bacteria decreased after the cultivation intensification, but amounts to less than 35%. Thus, the PYATd10 compound exhibits antimycobacterial activity towards M. lufu, being slightly inferior to the dapsone comparative drug by this type of activity.
Highlights
Проведен анализ антимикобактериальной активности производного диазинона ПЯТd10 и дапсона
We have carried out the analysis of antymicobacterial activity of PYATd10 diazinon derivative and dapsone
The capability of PYATd10 compound and dapsone drug to suppress the growth of M.lufu culture was studied by the method of serial dilutions
Summary
Проведен анализ антимикобактериальной активности производного диазинона ПЯТd10 и дапсона. Способность соединения ПЯТd10 и препарата дапсон подавлять рост культуры M.lufu исследовали методом серийных разведений. Визуальная оценка посевов на среде Школьниковой показала, что при концентрации соединения ПЯТd10 128 мкг/мл роста микобактерий не наблюдается, в то время как минимальная подавляющая концентрация дапсона была равна 32 мкг/мл.
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