Study effects of vitamin D deficiency on hematological and some physiological parameters among population in Derna City, Libya

Abstract

This work was carried out to investigate the changes in hematological and some physiological parameters among patients diagnosed with symptoms related to deficiency of vitamin D (VD) at Derna City, Libya in nine consecutive months (March to November 2020). A total of 110 adult patients were divided into two groups based on the deficiency and non-deficiency of VD. The percentages of positive group were 21 (19.09%) males, 69 (62.72%) females and that of the negative groups were 4(3.63%) males and 16 (14.54%) females. Highest prevalence with positive VD deficiency was noted in age group 21-50 years. From all patients, blood samples were collected for multiple tests including complete blood counts (CBC), liver function and kidney functions. Red blood corpuscles (RBC) count and Hematocrit (HCT) were decreased with statistically different compared to control. Also Hemoglobin (HGB) concentrations and mean corpuscular hemoglobin (MCH) were decreased when compared to control subjects in both genders. Mean corpuscular hemoglobin concentration (MCHC) was significantly decreased in patients (males and females) compared to control subjects. The numbers of white blood cells (WBC), percentage number of lymphocyte and parameters of platelets were not changed in both genders. While number of granulocyte was increased with significantly difference in positive VD deficiency. Mean levels of liver function parameters Aspartate aminotransferase, Alanine aminotransferase (AST and ALT), Total bilirubin (T .bilirubin) and kidney function parameters (creatinine and urea) were in normal range in all patients. The mean Calcium and ferritin values at patients with VD deficiency were significantly lower in both female and male subjects. In conclusion, VD deficiency is now recognized as a pandemic diseases common and found in both genders a cross different age groups and has effect in hematological and physiological parameters that studied.