Study effect of Breast Cancer on Some Hematological and Biochemical Parameters in Babylon Province, Iraq

Abstract

This is a cross sectional study of variations of Hematological and biochemical parameters among female breast cancer patients and apparently healthy individuals in Babylon province 30 breast cancer patients from daily clinic and private hospitals and 20 control individual were studied between January and June, 2013. Questionnaires for bio data administered to both the patients (cases) and control subjects. Hematological parameters were run on the EDTA samples for packed cell volume (PCV), white blood cell count (WBCs),red blood cell count (RBCs), platelet count, lymphocytes count using(Auto-Hematology Analyzer-, Hungary2011). Erythrocyte sedimentation rate (ESR) also performed on the sodium citrate samples using the Western green method. Significant differences (p 0.05) among patients.The mean PCV, RBCs and WBCs,platelet count, lymphocyte value were lower in patients compared to the controls with statistically significant differences (p<0.05). However, the mean ESR value significantly higher than the control subjects (p < 0.05). This study has shown that anemia; leucopenia and thrombocytopenia were common basic features to be considered in breast cancer patients while the biochemical parameters included the level of estrogen, progesterone hormones, cholesterol, triglycerides, lipoproteins (HDL, LDL), some immunoglobulin's (IgG, IgA and IgM) also had been measured in the study. The results demonstrated significantly high values of estrogen, progesterone hormones, triglyceride, LDL, HDL, cholesterol, and significantly high values in immunoglobulin's IgA, IgG,and IgM.in breast cancer in comparison with control group,