Abstract
The earlier pathomorphological studies of toxic properties of peat humic acids (PHAs) at intraperitoneal injection revealed that one of the causes of lethality is the direct cardiotoxic action of PHAs. For the further study of the mechanism of cardiotoxic action, electrocardiogram was recorded and ventricular fibrillation threshold was determined in male rats after intraperitoneal injection of humic acids in knowingly lethal dose – 480 mg/kg bwt. A single intraperitoneal injection of PHA to rats in knowingly lethal dose caused a significant decrease of the ventricular fibrillation threshold in comparison with intact animals. It was found that the PHA injection exerted no significant effect on the heart rate in rats and change of the PQ, QT, and QTc intervals. At the same time, the significant shortening of the QRS complex in comparison with intact animals was observed. Judging from the results obtained, the single injection of humic acids in the lethal dose induced a decrease in the electrical stability of heart, as evidenced by the drop of the ventricular fibrillation threshold. This decrease of the electrical stability of heart can be a cause of sudden cardiac death of trial rats. Disorder of the heart electrical stability is likely connected with the ionophoric action of humic acids and change of electrophysiological properties of cell membranes.
Highlights
For the further study of the mechanism of cardiotoxic action, electrocardiogram was recorded and ventricular fibrillation threshold was determined in male rats after intraperitoneal injection of humic acids in knowingly lethal dose – 480 mg/kg bwt
It was found that the peat humic acids (PHAs) injection exerted no significant effect on the heart rate in rats and change of the PQ, QT, and QTc intervals
Judging from the results obtained, the single injection of humic acids in the lethal dose induced a decrease in the electrical stability of heart, as evidenced by the drop of the ventricular fibrillation threshold
Summary
ИССЛЕДОВАНИЕ КАРДИОТОКСИЧЕСКИХ СВОЙСТВ НАТИВНЫХ ГУМИНОВЫХ КИСЛОТ ТОРФА Белоусов М.В.1, Ахмеджанов Р.Р.2, Зыкова М.В.1, Маслов Л.Н.3, Гурьев А.М.1, Юсубов М.С.1, 2. Проведенными ранее патоморфологическими исследованиями токсических свойств гуминовых кислот торфа (ГКТ) при внутрибрюшинном введении было установлено, что одной из причин гибели экспериментальных животных является их прямое кардиотоксическое действие. Однократное внутрибрюшинное введение ГКТ крысам в заведомо летальной дозе вызывает значительное снижение порога фибрилляции желудочков в сравнении с интактными животными. Однократная инъекция гуминовых кислот в летальной дозе индуцирует снижение электрической стабильности сердца (ЭСС), о чем свидетельствует падение порога фибрилляции желудочков. Судя по результатам проведенного патоморфологического исследования, одной из причин летальности при внутрибрюшинном введении ГКТ может быть их прямое кардитоксическое действие [14]. Цель исследования – оценить влияние нативных гуминовых кислот торфа на показатели электрической стабильности сердца и определить порог фибрилляции желудочков крыс после внутрибрюшинного введения в заведомо летальной дозе
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