Study Association of Serum Immunoglobulins and Non-Alcoholic Fatty Liver Disease in Egyptian Patients

Abstract

Abstract Background Non-alcoholic fatty liver disease represents a spectrum of liver diseases which occurs in the absence of alcohol consumption, it has become a clinical burden around the world because of its independent relationship with increased risks of cardiovascular disease, hyperglycemia and tumor malignancy, as an example it's the most common chronic liver disease in North America, with reported prevalence rates of 10%–50% in the general population. However, only 10%–30% of NAFLD patients progress to advanced fibrosis, cirrhosis, and/or hepatocellular carcinoma. Aim of the Work The aim of this study was to further investigate the association between NAFLD and the serum immunoglobulins. Patients and Methods Atotal of one hundred Egyptian people were enrolled in the study and divided into two groups: Group 1: 50 patients with non-alcoholic fatty liver disease diagnosed by clinical, laboratory and radiological investigations. Group 2: 50 patients with non-alcoholic steatohepatitis diagnosed by clinical, radiological features of NAFLD and elevated liver enzymes. Results Results of the present study revealed that the mean age of NAFLD was 44.4±9.3 and in NASH 50.6±8.5. In our study it was proven that Nafld prevalence increases with age. Concerning gender in our study there was predominance of female gender in NASH group by about 70% but in NAFLD they represent only 48%. In our study, it was proven that BMI and waist circumference were signifcnatly higher in NASH group. DM were signifciantly more frequent in NASH group. In the present study, there was no significant difference between the studied groups regarding hemoglobin, TLC and platelets. Conclusion Our results revealed that IgA was significantly higher among NASH group, IgM and IgG were significantly higher among NAFLD group. Results of this study showed statistically significant relation between ALT, AST, GGT and INR and degree of steatosis, they were higher among NASH group and also the albumin was significantly lower among NASH group on the other hand bilirubin was non-significantly higher in NASH.