Abstract
The aims of this study was to estimate the total antioxidant activity level in serum among the Thalassemia Iraq patients. We estimated total free radical scavenging activity in the120 serum of Thalassemic patients their age range from 2-27years. The DPPH activity of serum ranged from 0.1-3.11µmol/ml, the mean serum level of total antioxidants in Thalassemia patients was significantly lower than the control group, and no relation to age or sex. We concluded that DPPH is useful for evaluating the total antioxidant capacity.
Highlights
Free radicals are highly reactive compounds inherently unstable, since they contain "extra" energy [1]. They are created in the body during normal metabolic functions or introduced from the environment, to reduce their energy load, free radicals react with certain chemicals in the body to produce reactive oxygen species (ROS), it interfere with the cell's ability to function normally [2]
It has been found that aqueousperoxyl radicals include the oxidation of phospholipids liposomal membranes, for example, the aqueous peroxyl radicals attack membranes and induce the oxidation of lipids and proteins to cause possible hemolysis [11]
Oxidative damage especially due to iron overload and depletion of antioxidant status play an important role in pathogenesis of thalassemias
Summary
Free radicals are highly reactive compounds inherently unstable, since they contain "extra" energy [1]. A number of major cellular defense mechanisms exist to neutralize and combat the damaging effects of these reactive substances The enzymatic system such as (superoxide dismutase, catalase, and glutathione peroxidase), functionsby direct or sequential removal of ROS. Non enzymatic defense consists of scavenging molecules such as (GSH, ubiquinols, uric acid) that are endogenously produced or derived from the diet (vitamins C and E, lipoidacid, selenium, riboflavin, zinc, and the carotenoids). These antioxidant nutrients occupy distinct cellular compartments and among them; there are active re-cycling [5]. Aims of this study to estimate the total antioxidant activity level in serum among the Thalassemia in Iraqi patients
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