STUDY AND SELECTION OF A MODEL SOLUTION CONTAINING ANTIBIOTICS TO DEVELOP AN EAR DROP TO TREAT OTITIS MEDIA

Abstract

Introduction. Otitis media is an infection of the middle ear, it happens in the space behind the eardrum which contains the tiny vibrating bones of the ear. it divided into acute otitis media (AOM), suppurative otitis media (SOM) and otitis media with effusion (OME). Otitis is the most common specific disease in children, children aged 0–12 registered in 62 practices (1 March 2019–29 February 2020) and (1 March 2020–28 February 2021) were includ-ed, and secondly, the problem of treating acute otitis media in of adults remains one of the most urgent problems of modern otolaryngology, treat-ment may begin with clear up pain and sometimes, antibiotics are used to clear the infection. The aim of the study – development of a therapeutic solution containing an antibiotic from fluoroquinolones group for the treatment of acute otitis media. Material and methods. Viscometer VPZH-2 0.39 EKROS, RUSSIA, Milwaukee MC120 PRO pH Monitor, Electronic stirrer. Analytical scales Sartogosm CE224-S. Preparation of HEC solutions, preparation of HPMC solutions. polymer solutions prepared according to USP standards. Results. The physical characteristics of the obtained mixtures were studied and the compositions of the model mixtures are shown. The solution, which contains benzyl alcohol, ofloxacin as active ingredients and HPMC with 70% ethanol as excipients, is fully meets the requirements of ear drops. Conclusions. Solution, which contains benzyl alcohol, ofloxacin as active ingredients and HPMC with 70% ethanol as excipients, has suitable viscosity and pH, which are fully meets the requirements of ear drops.