Study an effect of various orgainic solvents for preparation of glipizide mucoadhesive microspheres

Abstract

Glipizide is a potent, rapid-acting with short duration of action and well tolerated second-generation sulfonylureas effective in reducing postprandial glucose level. However, if a dosage is missed before a meal, the risk of postprandial hypoglycemia and post-meal glucose excursions is always linked with the use of glipizide for the treatment of type 2 diabetes mellitus. Type 2 diabetes mellitus is a polygenic illness that includes both insulin secretion dysfunction and peripheral insulin resistance. (1)The study an effect of organic solvents preparation of glipizide controlled released mucoadhesive microspheres. (2)The microspheres were formulated conventional tremendous technique by emulsion solvent evaporation technique. (3) Mucoadhesive microspheres were evaluation parameters Examine by their impact on mucoadhesion, drug encapsulation efficacy (EE%), and in-vitro drug release. The produced microspheres were subjected to physical characterizations such as FTIR, DSC, particle analyzer, and SEM. Using cock stomach tissue, the ex-vivo mucoadhesive properties of the various orgainic solvents microspheres were studied. When compared to the other solvents microspheres employing, such as ethanol, methanol, acetone, glipizide loaded ethanol mucoadhesive microspheres had a higher EE percent (83.63±0.17%), a more sustained release profile over 10 hours, and superior adherence to cock stomach mucosa.