Abstract
The original Japanese observations on kanamycin are confirmed as to activity in vitro and in mice. They are extended to include: (a) cross-resistance studies, (b) experiments with kanamycin A and B singly and together, (c) combined therapy experiments with other tuberculostatic agents.Samples of kanamycin A and A plus B were of the same order of activity as streptomycin in vitro and in mice, and were effective against streptomycin-resistant organisms. Kanamycin B did not increase mouse survival when tested at a level that with kanamycin A gave good prolongation of life. When mice were treated with combinations of kanamycin plus streptomycin, or dihydrostreptomycin, or neomycin, the survival increases obtained were greater than were to be expected from the mere sum of the effects of the individual antibiotics.
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