Abstract
The original Japanese observations on kanamycin are confirmed as to activity in vitro and in mice. They are extended to include: (a) cross-resistance studies, (b) experiments with kanamycin A and B singly and together, (c) combined therapy experiments with other tuberculostatic agents.Samples of kanamycin A and A plus B were of the same order of activity as streptomycin in vitro and in mice, and were effective against streptomycin-resistant organisms. Kanamycin B did not increase mouse survival when tested at a level that with kanamycin A gave good prolongation of life. When mice were treated with combinations of kanamycin plus streptomycin, or dihydrostreptomycin, or neomycin, the survival increases obtained were greater than were to be expected from the mere sum of the effects of the individual antibiotics.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.