Abstract
We studied the effects of antiserum against rat peripheral nervous system (PNS) myelin, rat or chicken central nervous system myelin basic protein (BP), or rabbit P 2 protein from PNS myelin on myelinated cultures containing only rat dorsal root ganglion neurons and Schwann cells. While anti-PNS myelin serum consistently produced segmental PNS demyelination, anti-BP serum and anti-P 2 serum did not. The culture results suggest that the myelin PNS proteins P 1 (identical to basic protein from central nervous system myelin) and P 2 are not exposed on the extracellular surfaces of myelin-related Schwann cells in tissue culture.
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