Abstract
Derivatives of the serotonin reuptake inhibitor 4-(5-fluoro-1 H-indol-3-yl)cyclohexylamine, in which serotonin 1A (5-HT 1A) receptor pharmacophoric elements are incorporated, are reported. Analogs exhibiting affinity for both the serotonin transporter and the 5-HT 1A receptor are described. Compounds containing 1-(4-indolyl)piperazine and 2-(1 H-indol-4-yloxy)ethylamine are promising leads for further SAR studies.
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