Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2 H-benzo[1,4]oxazine derivatives with dual 5-HT 1A receptor and serotonin transporter affinity

Abstract

The design, synthesis, and structure–activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT 1A receptor activities are described.