Abstract
The methyl 3-methylene-7-phthalimidocepham-4-carnoxylate 3, the corresponding (R)-oxide 2 and the 1,1-dioxide 1 add bromine affording stereoisomeric mixtures of dibromoderivatives. These results are at variance with previous reports regarding 3-exomethylene sulfides and sulfoxides. The stereochemistry of the dibromoderivatives was unambiguously determined via X ray crystallography of 5a, following 1H-NMR correlations. The single dibromo derivatives as well as the isomeric mixtures, can be dehydrobrominated to afford 3-bromomethyl cephem derivatives (7,8,9) in very good yields.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
