Abstract
Summary The seven step chemical synthesis of 3-deoxy-lα,25-dihydroxyvitamin D3 from 1α,25-dihydroxycholesterol is described. This steroid is a potentially most interesting analog of the hormonally active form of vitamin D3, 1α,25-dihydroxyvitamin D3 since it lacks only the 3β-hydroxyl group. The newly synthesized steroid stimulated intestinal calcium transport virtually as effectively as 1α,25-dihydroxyvitamin D3. Further, the new compound is the most effective analog known to date in terms of its ability to compete with 1α,25-dihydroxyvitamin D3 in an in vitro intestinal receptor assay.
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