STUDIES ON VASCULAR PERMEABILITY AND MUCOSAL ABSORPTION IN THE FIELD OF OTO-RHINOLOGY

Abstract

Absorption ability of nasal septum mucosa in healthy subjects and those with spontaneous nasal bleeding was compared using normal saline containing radioactive Na24. Fundamental experiments concerning absorption and permeation also performed using radioactive I131 and guinea pigs. Results were as follows:1) Comparing with healthy subjects, cases with spontaneous nasal bleeding showed an increase in fluid absorption through nasal septum mucosa, in parallel with an increase in system vascular permeability.2) In sensitized guinea pigs, fluid and protein absorption ability was increased in the early stageeven before the manifestation of morphogical changes. Protein permeability was also slightly increased.3) At the site of local anaphylaxis, in the early stage, there was a difference in the speed of fluid absorption through the mucosa and skin. Absorption through the mucosa was faster than that through the skin.4) No change in fluid absorption was seen in guinea pigs with anemia due to experimental blood loss or with vitamin C deficiency.5) Absorption ability, like permeation ability, is one of the characteristics of blood vessels. The examination of absorption ability presents an important guide in diagnosis, evaluation of the prognosis; and treatment of the diseases.