Abstract
Urinary estrogen fractions in patients with fibroadenoma were measured in three times, Postmenstrual, ovulatory and premenstrual phases. Two dimensional thinlayer-chrmato-ography was used as Purification and fractionation procedures. Fibroadenoma showed a little cyclic change in the 2 nd and 5 th decade such as in the control group, but much cyclic change in the 3 rd and 4 th decade. However, in the latter decade, urinary estrogen level was slightly lower than in normal control group. There was same tendcncy in urinary estrogen fractions as in the total estrogens, although some fluctuations were 'seen in each group. Total estrogens level in breast-cancer and fibroadenoma was lower than that of mastopathy. Estrone fraction in breast-cancer was lower than the other two groups in the 5 th decade. On estriol fraction, patients with mastopathy were in higher excretion level in the 4 th decade, but in the 5 th decade, that of breast-cancer patients was higher than the other two groups.
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