Abstract
We have developed a charcoal suspension, injectable intratumorally into tattooed human breast tumors prior to chemotherapy and surgery, to guide the surgeon during the removal of residual tumor after response to treatment. Since some tumors are highly vascularized and since intratumor injections of the charcoal particles may occasion systemic effects, we studied in vivo toxicity. An intravenous injection of 4 mg (166 mg/kg) to 2 month-old mice (24 g average) was immediately lethal, but the same dose given intraperitoneally or lower doses administered intravenously (400 μg (16.6 mg/kg), 40 μg (1.66 mg/kg), 2O μg (0.83 mg/kg) had no effect. Charcoal was localized in the organs up to day 30. The in vitro addition of charcoal (0.2–4 mg/ml) to cell lines strongly inhibited their growth and their clonogenicity, indicating that the probability that tumor growth is stimulated in vivo after charcoal injection is implausible.
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