Abstract
Abstract Introduction In a recent report from this laboratory (1), a method was described which makes possible the study of some aspects of the union between specific antigen and the skin of horse serum-immunized rabbits. The method embraces the interplay between two types of immune reactions: diphtheria toxin with antitoxin and horse serum antigen with the skin of horse serumimmunized rabbits. The method is an indirect one, being based on the observation that horse serum diphtheria antitoxin does not possess the same neutralizing range for diphtheria toxin in normal and in horse serum-immunized rabbits in vivo. If a lethal amount of diphtheria toxin and its neutralizing quantity of antitoxin are injected some distance apart into the skin of both a normal rabbit and a horse serum-immunized rabbit, the former animal will survive and the immunized one will succumb. In the normal rabbit, the toxin and the antitoxin apparently diffuse from the area of injection and neutralization of the toxin takes place in vivo.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
