Abstract
Abstract The injection of killed cultures of bacteria in animals leads to their development of specific immunity and tissue hypersensitiveness. Much is known regarding the nature of acquired immunity, especially with reference to antibody production, but relatively little appears to be known regarding acquired sensitivity. For over a year we have been investigating quantitative aspects of sensitization to different organisms, utilizing the albino rabbit as the experimental animal. During that period we have become more and more impressed with the extent to which sensitivity or, to use the widely accepted term, allergy is a marked and constant response of the rabbit to repeated injections of bacterial suspensions in the tissue. It was stated in connection with our studies on sensitization to proteins (1), that tissue hypersensitiveness frequently exists in the absence of serum precipitins.
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