Abstract
The nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate glycohydrolases of subcellular fractions of spleen and blood of normal and tuberculous guinea pigs were studied. The soluble glycohydrolases that appeared in the spleen and liver after onset of the disease had kinetic characteristics that differentiated them from the particulate enzymes of normal tissue and suggested a common synthesis with the nuclear glycohydrolases. The soluble glycohydrolases that were also present in the plasma of the diseased animals had kinetic characteristics that differentiated them from other soluble glycohydrolases. Nicotinamide is an allosteric inhibitor of some of the glycohydrolases.
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