Abstract
In the present work, stability studies, microbiological study, ocular irritation studies and ocular permeation studies were performed on prepared thermoreversible gels of Azithromycin. Franz-diffusion cell consisting of a receptor cell and donor cell was used for trans-corneal permeation studies. Out of several developed Formulations, Formulation code A was selected on the basis of in vitro release studies, and was subjected to trans-corneal permeation studies through a goat's corneal membrane. The developed thermoreversible in situ gel was found to be stable, non-irritant, passing the sterility test, having antimicrobial activity and sustained drug release profile.
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