Abstract
The appearance and distribution of amyloid formed experimentally in mice by repeated injections of aqueous Trypan Blue dyebwas studied by means of differential polarized light. This method, which differs from conventional polarization by insertion of a quartz wedge into the optical pathway of the polarizing microscope, revealed findings of significance. It was observed that the usual bright green birefringence in parenchymous organs is replaced by two colors: orange, which initially appears at about 28 days; and green, which predominates after about 130 days. The orange color is interpreted as being compatible with immature (young) arnyloid; the green color with the mature form of this substance. These data would confirm previous studies suggesting that all arnyloid present in an organ is not of the same age.
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