Abstract

<h2>Summary</h2> The excretion of ascorbic acid in the urine and its concentration in the plasma have been studied in seven cases of proved scurvy. Absolute depletion of ascorbic acid in the urine and very low values in the plasma were found. Vitamin replenishment was accomplished quickly or over a long period of time, depending primarily on the dose of ascorbic acid employed. In three groups of infants comprising well babies, babies picked at random from the ward, and patients with scurvy, concentrations of ascorbic acid in the plasma were demonstrated generally characteristic of optimal, suboptimal, and deficient intake of vitamin C. The limitations of the method and significance of results are discussed.

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