Abstract
Established baby hamster kidney cell lines (BHK 21, C 13, 1BH 3) may produce tumors when 1000 cells or more are injected subcutaneously in adult hamsters. Highly tumorigenic and low tumorigenic cell clones can be selected from such cell lines by growing dispersed cells in the presence or absence, respectively, of CO 2. Highly tumorigenic cell clones will produce tumors with as few as 10 cells, whereas the nontumorigenic clones will produce only an occasional tumor when 10 5 to 10 6 cells are injected. The arrangement of the cells in respect to each other in the cell culture was not correlated with the tumorigenic property. Various degrees of piling up and acidity are exhibited by the different cell cultures.
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