STUDIES ON THE TOTAL SYNTHESES OF MAYTANSINOIDS (III)——SYNTHESIS OF C 5 -N FRAGMENT

Abstract

The synthesis of an important intermediate, C 5 -N fragment of maytansine, is described in this paper. This fragment possesses aromatic moiety, two conjugated trans-double bonds and three asymmetrical carbons, C 6 , C 7 , C 10 , of maytansine.