Abstract
Studies are reported on the detection and in vitro biosynthesis of prostaglandins in the vesicular glands of hypophysectomized and essential fatty acid-deficient rats. The vesicular glands of the hypophysectomized rats underwent rapid degeneration and were depleted of their stores of arachidonic acid and prostaglandins. Hypophysectomy also inhibited the in vitro conversion of arachidonic acid to prostaglandin E 2 with the vesicular gland of rats. The vesicular glands of essential fatty acid-deficient animals also became depleted of their stores of prostaglandins and arachidonic acid, as well as linoleic acid, and lost their activity for the in vitro conversion of exogenous arachidonic acid to prostaglandin E 2.
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