Abstract
In order to examine more advantageous syntheses and the structure activity relationship, derivatives of 1, 2, 3, 4-tetrahydro-5H-benzazepine were synthesized via two routes from 3, 4-dihydro-1(2H)-naphthalenone. First, these compounds were synthesized via Beckmann rearrangement of 3, 4-dihydro-1(2H)-naphthalenone oximes and second, via 2-(2-cyano-1, 1-dimethylethyl)-4-methoxybenzoic acid. The synthesized compounds were tested for analgesic activity in mice.
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