Abstract
In order to discuss the possibility of the contribution of the chelating ability to the radioprotective activity in cysteamine, effects of copper (II) ion to the formation of the mixed disulfide was investigated in the systems of cysteamine and cysteine, glutathione and albumin respectively as the reactions between two kinds of thiol compound and in the system of cystamine and cysteine as the reaction between disulfide and thiol compound by the use of 35S-cysteamine or 14C-cysteine. Separations of the mixed disulfides were achieved by electrophoresis and amounts of the mixed disulfides were estimated by the measurement of radioactivity. Remarkable catalytic effects were observed depending upon the reaction conditions. Whereas inhibitive effects were observed in some cases. Relationship between the effect of copper (II) ion and the reaction condition was discussed and an intermediate copper chelate was presumed for the reaction mechanism.
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