Abstract
The volumes of the stromal (interstitial), luminal and foUicular cell compartments of rat and guinea pig thyroid glands in various experimental conditions have been measured by radioactive indicators and the results have been compared with volumes determined by histological measurements. The volume of distribution of 14C-inulin was found to be the same as that of the stroma as determined by a histological procedure. Thus, inulin is a measure of stromal volume in the thyroid gland. Neither TSH, chronic PTU treatment, nor hypophysectomy altered the inulin space in the thyroid of rats or guinea pigs. In rats the volume of distribution of 38SO4- corresponded with the combined stromal and luminal volumes as determined by inulin and histological measurements, respectively. In guinea pigs the 36SO4- space was less than the sum of the inulin space and the histologically determined luminal volume. The difference is explained by the large amount of negatively charged colloid protein in the lumen of the guinea pig a...
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