Abstract
The effects of ovulation-inhibiting steroids on plasma LH and FSH levels and the response to iv administration of LH-releasing hormone (LH-RH) were investigated in rats. Plasma LH levels were measured by ovarian ascorbic acid depletion (OAAD) assay and by radioimmunoassay (RIA). Plasma FSH was also measured by RIA. Subcutaneous administration of large doses of megestrol acetate, lynestrenol, Schering AG compound SH 1040 and Ayerst compound AY 11440 or of small daily doses for 5 days of combinations of megestrol acetate with ethinyl estradiol (Ovex) and lynestrenol with mestranol (Lyndiol), significantly depressed plasma LH levels in ovariectomized rats. The same compounds in large doses also depressed serum FSH levels, but small doses of Lyndiol and Ovex did not do so. Large doses of Lyndiol, Ovex, Schering AG compound SH 1040 and a combination of AY 11440 with ethinyl estradiol did not suppress the stimulatory effect of minute amounts (0.11–0.16 μg) of LH-RH on LH release (3- to 10 fold increase). Simila...
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