Abstract
ABSTRACT The effects of ovulation inhibiting steroids on plasma luteinizing hormone (LH) levels and on the response to LH-releasing factor (LRF) were studied in an attempt to learn whether these compounds exert part of their effect on the pituitary or on the hypothalamus. Ovariectomized rats were injected subcutaneously for 5 days with estrogens, progestins, and combinations thereof. Plasma LH levels were measured by the ovarian ascorbic acid depletion assay. The progestins: chlormadinone acetate (0.05–10 mg), ethynodiol diacetate (2 mg), norethynodrel (20 mg), norethindrone (5 mg), medroxyprogesterone (10 mg), norgestrel (1 mg) and dimethisterone (2.5–20 mg) given daily in doses indicated significantly depressed plasma LH. Administration of mestranol (0.001–0.2 mg) and ethinyl estradiol (0.1 mg) also significantly lowered plasma LH. The progestin/estrogen combinations: chlormadinone acetate/mestranol (C-Quens, 10.4 μg), ethynodiol diacetate/mestranol (Ovulen, 5.5 μg), norethynodrel/mestranol (Enovid, 12....
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