Abstract

1. 1. Mice immunized with H. pertussis are slightly more resistant to high doses of histamine (8 mg.) than they are to lower doses (0.5 to 2 mg.). 2. 2. The resistance of these mice to high doses of histamine can be greatly increased by treating the mice with propylene glycol, 5 per cent starch, 0.005 per cent colchicine, 0.5 per cent aspirin, and weak NaOH solutions, etc. 3. 3. Normal mice do not give this type of response to histamine.

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