Abstract
THE adrenal gland has been suspected of involvement in allergic conditions for over 20 years. In an early paper Wyman (1929) reported that adrenalectomized rats with adrenal transplants in the abdominal muscles were as susceptible to histamine poisoning and anaphylactic shock as adrenalectomized rats without transplants, but treatment with adrenalin somewhat alleviated this susceptibility. In a later paper, however, Wyman and Turn Suden (1937) reported the lethal doses of histamine to be as follows: normal rats, 100 mg. per kg. of body weight; adrenalec-tomized rats, 10 mg. per kg.; and adrenalectomized rats with adrenal transplants, 40 mg. per kg. Ingle (1937) also showed that autoplastic cortical transplants do not completely replace the function of the excised gland in rats. Perla and Gottesman (1931) found that adrenal cortical extract decreased the susceptibility of adrenalectomized rats to histamine and suggested that this property could serve as a basis for a cortical hormone assay.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
