Abstract
We investigated the influence of brain focal injections of 2-amino-7-phosphonoheptanoate (APH), N-methyl-D-aspartate (NMDA), muscimol and 2-chloroadenosine (CAD) on behavioural symptoms of the high pressure neurological syndrome (HPNS) in rats. Each compound was bilaterally injected (in nmole range doses) into the substantia nigra pars reticulata (SNR), entopeduncular nucleus (EP) or ventromedial thalamic nucleus (VLTh) prior to exposure to hyperbaric conditions. Threshold pressure for the occurrence of tremor, myoclonic jerks and convulsions were recorded for drug and vehicle-injected animals. A decrease in threshold pressure for a particular symptom indicates that the reaction to hyperbaric conditions is more pronounced, while an increase in threshold pressure is indicative of protection against HPNS.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
