Abstract
Monoamine oxidase (MAO) inhibitor-induced potentiation of the pharmacological actions and toxicity of meperidine, in man and experimental animals, is well documented (for literature see Penn and Rogers, 1971). The same is not true for morphine. There are reports which suggest that unlike meperidine, morphine toxicity in man is seldom enhanced by prior treatment with MAO inhibitors (Palmer, 1960; Shee, 1960; Brown and Waldron, 1962). Other workers (Mustala and Jounela, 1966; Rogers and Thornton, 1969; Bhattacharya, Raina, Banerjee and Neogy, 1971; Yeh and Mitchell, 1971), however, have shown that MAO inhibitors do potentiate the pharmacological actions and toxicity of morphine in experimental animals.
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