Studies on the relationship between gene polymorphism of metabolizing enzymes and susceptibility to bladder cancer

Abstract

Bladder cancer is one of the most common cancers of the urinary system. However, the exact mechanism underlying bladder cancer is still unclear. Now, more and more people have realized that evolution process of bladder cancer is a multi-genomic, multifactorial process in diversification, which is the result of a combination of genetic and environmental factors were in smoking and occupational exposure (aromatic compounds such as benzidine, beta-naphthylamine, etc.) are the most common environmental factors leading to the development urinary bladder cancer. It extremely interesting that some people never get bladder cancer despite exposure to certain chemicals. In contrast, many patients with bladder cancer are not exposed to known risk factors. This suggests that genetic factors may play an important role in the progression of bladder cancer. As a clue, domestic and foreign studies have found that many metabolic enzymes have a significant correlation with bladder cancer susceptibility. In human body, the activation and inactivation of exogenous chemicals of various metabolic enzymes have played an important role, so that the susceptibility of bladder cancer is affected by the genetic polymorphism of metabolic enzymes in the different individuals exposed to pathogenic factors. Therefore, whether the exposed individual is more susceptible to bladder cancer also depends on the genetic polymorphisms of the metabolizing enzymes. Research purposes: The target of this study was to detect the susceptibility of bladder cancer by the gene polymorphism of the metabolic enzymes in the human body, reveal potential risk factors of bladder cancer, and provide intervention or treatment actively to prevent or slow down the tumorigenesis and its development. Key words: Bladder cancer; Aromatic compounds; Metabolic enzymes; Gene polymorphism; Genetic susceptibility