Abstract
Histological investions were carried out on injury in stomach mucosa which is induced by taking high salt food, and which is considered to make a ground f or the development of stomach cancer, and efficacy of calcium against this was examined.When rats were given high salt food, gastric mucosa underwent such severe changes as remarkable deaquamation and loss of surface epithelium, and atrophy of cytoplasm of both parietal and chif cells to spherical forms, finally resulting in ersion. When, however, this food was given together with a sufficient amount of calcium, no such alterations were produced, and the mucosa was maintained in the normal state. This clearly indicates that the injury by salt in stomach mucosa was prevented with calcium.It is considered from these results that habitual intake of high salt food will injure stomach mucosa, producing a picture of the so-called chronic gastritis, and that calcium, which exerts preventive effect against this, will inhibit the development of cancer if the ground for this is really provided by the above mentioned injury.
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