Studies on the regulation of hepatic bile flow: The intestinal phase of biliary secretion

Abstract

<h2>Summary</h2> Eight mongrel dogs were prepared with cholecystectomy, ligation of the minor pancreatic duct, gastric and duodenal cannulas, and Thiry-Vella fistulas of the total duodenum and jejunum. Perfusion of the distal duodenum or jejunum with acid caused significant increases in biliary volume and bicarbonate concentrations as well as gastric acid output. Acid perfusion of the jejunum also caused an increase in chloride concentration. Responses similar to those of jejunal perfusion were noted when cholecystokinin-pancreozymin, 2 units per kilogram per hour, was given intravenously. Although the additional simultaneous infusion of secretin, 4 units per kilogram per hour, accentuated the changes in biliary volume and bicarbonate concentration, gastric acid output was reduced. Perfusion of the duodenum with a 5 per cent Bacto-Peptone solution caused no significant change in biliary flow. The physiologic effects of acid perfusion of the distal duodenum or jejunum are best explained by the simultaneous release of both secretin and cholecystokinin-pancreozymin.