Abstract
Studies on the immunosuppressive effect of cyclophosphamide on the primary and secondary immune responses to sheep erythrocytes of both young adult and aged mice were performed with a quantitative evaluation of antibody-producing spleen cells and serum antibody titers. Cyclophosphamide, administered 30 min before primary immunization, resulted in complete suppression of the primary immune response, but the drug did not inhibit effective priming for the secondary response either in young adult or in aged mice. After treatment with cyclophosphamide, multiple necroses were observed in 5 of 30 spleens of aged mice, obviously due to bacterial infections. Such necroses, exclusively found in the group of aged mice, did not impair the antibody-forming potential to a significant degree. On the basis of these findings it is suggested that the immunosuppressive treatment of aged individuals results in an impaired efficiency of the defense mechanisms as compared to young adult animals.
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