Abstract
Previous experiments have revealed changes in the metabolism of nieotinic acid and nicotinamide-adenine dinucleotides due to CS 2 intoxication. In this study the incorporation of tryptophan into nicotinamide-adenine dinucleotides in the liver of rats chronically intoxicated with CS 2 has been measured. The concentration and radioactivity of NAD in the liver of rats were determined 5 hr after administration of a loading dose of tryptophan and 2 hr after injection of a trace dose of [ 14C]tryptophan. It was found that tryptophan was more extensively incorporated into nucleotides in the liver of rats intoxicated with CS 2. This indicates, that tryptophan, rather than nicotinic acid, is the main precursor of NAD synthesis in animals intoxicated with CS 2.
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