Abstract
Nanoparticles were obtained by nanoprecipitation and by emulsion solvent evaporation (ESE) method. In the ESE method, the size of the particles depended on the type and concentration of surfactant (in the water phase) and the polymer concentration (in the organic phase). The best results were obtained with ionic surfactants, however, the use of such compounds may accelerate the degradation process of polymers. In the nanoprecipitation method, the ratio of solvent (methylene chloride) to non-solvent (hexane) has a significant influence on the particle size. The smallest particles were obtained with a solvent to non-solvent ratio of 1:150.
Highlights
Polymeric nanoparticles are considered as useful carriers in controlled drug delivery systems
The aim of this work was to obtain nanoparticles from polyanhydride based on betulin disuccinate and to evaluate the influence of the preparation conditions, including: Homogenization time, type of surfactant and concentration of the polymer solution, on the shape, morphology and size of particles
Polyanhydrides based on disuccinate betulin were successfully fabricated into nanoparticles
Summary
Polymeric nanoparticles are considered as useful carriers in controlled drug delivery systems. Due to their small sizes and high surface area, they have many advantages. Polymer-based nanocarriers may improve solubility and bioavailability of highly insoluble hydrophobic drugs, increase the stability of volatile pharmaceutical agents, or deliver a higher concentration of drugs to a desired location [1,2]. They can be used for treatment of various diseases, including bacterial and fungal infections, hypertension, asthma, or cancer [3]. Polymers used in nanoparticle formulation should be biocompatible, non-toxic, and non-antigenic [4]
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