Abstract

Nanoparticles were obtained by nanoprecipitation and by emulsion solvent evaporation (ESE) method. In the ESE method, the size of the particles depended on the type and concentration of surfactant (in the water phase) and the polymer concentration (in the organic phase). The best results were obtained with ionic surfactants, however, the use of such compounds may accelerate the degradation process of polymers. In the nanoprecipitation method, the ratio of solvent (methylene chloride) to non-solvent (hexane) has a significant influence on the particle size. The smallest particles were obtained with a solvent to non-solvent ratio of 1:150.

Highlights

  • Polymeric nanoparticles are considered as useful carriers in controlled drug delivery systems

  • The aim of this work was to obtain nanoparticles from polyanhydride based on betulin disuccinate and to evaluate the influence of the preparation conditions, including: Homogenization time, type of surfactant and concentration of the polymer solution, on the shape, morphology and size of particles

  • Polyanhydrides based on disuccinate betulin were successfully fabricated into nanoparticles

Read more

Summary

Introduction

Polymeric nanoparticles are considered as useful carriers in controlled drug delivery systems. Due to their small sizes and high surface area, they have many advantages. Polymer-based nanocarriers may improve solubility and bioavailability of highly insoluble hydrophobic drugs, increase the stability of volatile pharmaceutical agents, or deliver a higher concentration of drugs to a desired location [1,2]. They can be used for treatment of various diseases, including bacterial and fungal infections, hypertension, asthma, or cancer [3]. Polymers used in nanoparticle formulation should be biocompatible, non-toxic, and non-antigenic [4]

Objectives
Methods
Findings
Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.