Abstract
Rats were made thiamine deficient by thiamine deprivation and treatment with the thiamine antagonists, oxythiamine and pyrithiamine. Thiamine deprivation and oxythiamine treatment caused significant elevations of blood pyruvate and lactate, the changes being greatest after oxythiamine. Neither had any effect on plasma lactate dehydrogenase activity. Pyrithiamine-treated rats showed no elevation in blood lactate nor pyruvate if tested before convulsions started, but showed marked elevations in both, and also in plasma lactate dehydrogenase activity after 24–36 h in convulsions. No significant changes were observed in lactate dehydrogenase activity in brain and kidney in thiamine-deprived and pyrithiamine-treated rats, but an increase was observed in oxythiamine-treated rats. A decrease in lactate dehydrogenase activity was found in the heart in thiamine-deprived rats and in the liver of rats exhibiting all three types of experimental deficiencies. A decrease in the relative abundance of LDH 3 and LDH 4 isozymes and an increase in LDH 1 was observed in the hearts of thiamine-deprived, oxythiamine-treated and pyrithiamine-treated rats.
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