Abstract
Abstract Uniformly sized phosphatidylcholine liposome dispersions are prepared in different molecular weights ranging from 2 × 106 to 3 × 107 daltons by means of molecular sieve chromatography on a Sepharose 2B gel. A linear relationship between their partition coefficients on the gel, Kav, and log Mw determined by sedimentation equilibrium has been obtained. The relationship was found to hold both in the L-α-dipalmitoylphosphatidylcholine (DPPC) and egg phosphatidylcholine (egg PC) liposomes. In connection with the molecular weight determination, the partial specific volume of DPPC in the liposome dispersion was obtained as a function of temperature around its transition point, 25°C-48°C.
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