Studies on the Pharmacological Effects of Saraca Indica Leaf Extract on the Nerves of Mice

Abstract

Abstract: People in India think that the Ashoka tree, also called the Saraca indica tree, is one of the holiest plants. Ayurvedic doctors have used the properties of the Saraca indica plant for a long time to treat pain, promote a healthy complexion, help with digestion and absorption, stop thirst, get rid of all infectious agents, treat blood diseases and inflammation, and calm the central nervous system. The goal of this study was to find out if different extracts of Saraca indica leaves have any CNS-depressing effects. In earlier research, it was thought that Saraca indica might have a depressant effect on the central nervous system. This led to the current study. Because of their different levels of polarity, petroleum ether, chloroform, methanol, and water were used in this order to get the leaves of Saraca indica. The depressant effect of pentobarbitone on the central nervous system (CNS) was measured by timing how long it took for the drug to make the subject fall asleep and by tracking how much the subject moved with an actophotometer. At a dose of 400 mg/kg, an extract of Saraca indica leaves that was made with methanol showed the most helpful effects. Significantly (P 0.01), this dose both slowed down the time it took for pentobarbitone to cause sleep and made it last longer. When the extract was given, the amount of movement decreased by 67.33 percent. The effect of extracts in water, chloroform, and petroleum ether on the CNS was different depending on the dose. Even so, neither animal showed any clear signs of the CNS being slowed down by the petroleum ether extract. Based on what was found, some Saraca indica leaf extracts may make the CNS feel down.