Abstract
Objective To sum up the magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) characters in patients with concentric sclerosis, and to investigate the association between imaging and possible pathogenesis.Methods Three patients with clinically diagnosed concentric sclerosis underwent MR] and DWI, one of whom was additionally performed 1H-magnetic resonance spectroscopy imaging (1H-MRS).Results Multiple lesions of laminated demyelination alternating with spared white matter were demonstrated in all 3 patients, and the enhanced lesions appeared to be concentric coils.Rings of alternating hypointense and hyperintense layers were shown on the DWI image, with apparent diffusion coefficient alternating correspondingly to the layers of the histologically demyetinated and undemyelinated areas.Conclusions Balo' s concentric sclerosis has unique characteristics on MRI and DWI, which corresponds to changes in its pathology and provides evidence for a better understanding of its pathophysiologic mechanisms. Key words: Diffuse cerebral sclerosis of Schilder; Magnetic resonance imaging; Diffusionmagnetic resonance imaging
Published Version
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