Abstract
Metallic ions in the blood and the urine of the patient suffered from so-called “Minamata Disease” which is an encephalopathia of unknown cause were examined.Quantitative analysis of the manganese was investigated in patients as well as in cats which showed similar symptoms to the human. Furthermore, fish and shellfish obtained from the bay in the district of Minamata were also exmined.It was found that the amount of manganese was increased in the blood and urine of patients and cats, in liver of cats, in fish and in shellfish as compared to the control group s. It might be considered from the above results that the pathogenesis of “Minamata Disease” may be related to manganese intake by human and animals through fish and shellfish taken from the sea along this particular parts of the sea-coast.
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