Abstract

Reaction of methyl 5-O-tosyl-2, 3-O-isopropylidene-β-D-ribofuranoside (1) with the sodium salts of purines, (2) and (3), and pyrimidines, (12), (13), and (14) derivatives in DMF afforded the corresponding "reversed nucleosides". 6-Alkylaminopurine analogues were prepared by the reaction of the 6-methylthiopurine derivative (4) with the amines. After removal of the protective groups, the reversed nucleosides were oxidized by oxygen in dilute alkaline solution to afford easily eritadenine analogues as major products.

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