Abstract
With the recent availability of chemically pure and highly concentrated estrogenic products, the medical profession is confronted with the problems of the margin of safety, therapeutic indications and optimal dosage. In a previous study on the constitutional effects of relatively large doses of estrogens, we 1 found that the administration of from 100,000 to 260,000 rat units of the principle, given in divided doses over a period of from two to three months, produces no appreciable changes in body weight, basal metabolism, blood pressure, blood count, coagulation and bleeding times, blood chemistry and urine. The present study was undertaken in an attempt to evaluate the indications for the clinical use of estrogens, their respective optimal dosage and the most effective modes of administration. THE PHYSIOLOGIC EFFECTS OF ESTROGEN IN THE EXPERIMENTAL ANIMAL Clinical studies in optimal dosage of a new therapeutic agent are by necessity based primarily on the varied
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