Abstract
The 24-hour LD 50's of 30% and 50% ethanol and of secobarbitone sodium and phenobarbitone sodium, all administered intraperitoneally, and of 30% ethanol administered intravenously have been established in mice. The toxicity of a given amount of ethanol, administered intraperitoneally to mice, appears to be proportional to the concentration in which it is administered. Secobarbitone sodium and phenobarbitone sodium, when administered to mice in combination with ethanol, exhibit a negatively correlated independent additive joint action. Results of intravenous infusion of ethanol and pentobarbitone sodium, individually and in combination in the rabbit, confirm the conclusion that ethanol interacts with barbiturates in an independent additive fashion.
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