STUDIES ON THE NATURE OF FEVER RECOGNIZED IN PATIENTS WITH MALIGNANT TUMOR ON THE PYROGENIC SUBSTANCE OF MALIGNANT TUMOR

Abstract

1. There were many feverish cases in the patients of malignant tumor in which no complications had been found; and these fever-types were febris remittens et intermittens, febris continua, fever paroxysm similar to malaria, inconstant fever and slight fever etc., slight fever cases were more often seen. 2. After administrating antitumor-drugs to patients with malignant tumor, there were cases in which fever-types changed. Some cases with probably some pyrogenic substances in their malignant tumor tissue were observed. 3. After an injection of the water extract of malignant tumor tissue into the auricular vein of rabbits, increase of the body temperature was observed; on the other hand no variation of body temperature was observed by injecting intravenously the water extract of normal muscle tissue of a tumor-bearing-animal. 4. Increase of body temperature was observed immediately after injection of some dosis of the polysaccharide fraction extracted from the malignant tumor tissue into the auricular vein of rabbits; hypothermia appeared at first with remarkable increase of body temperature thereafter when the polysaccharide fraction was injected into the regio hypothalamica of rabbits. 5. No pyrogenic action was observed in the protein fraction or phospholipid fraction extracted from the malignant tumor tissue but was observed in the polysaccharide fraction extracted from the normal muscle tissue of tumor-bearing-animals. 6. Nitrogen-mustard N-oxide (MBAO) depressed the pyrogenic action of the polysaccharide fraction extracted from malignant tumor, but glucuronic acid, saccharogen and actinomycin did not influence the pyrogenic action of the abovementioned substance. 7. Among the polysaccharide fractions extracted from the malignant tumor administered with MBAO, glucuronic acid and actinomycin, there were cases in which the-pyrogenic action of these polysaccharide fractions decreased; the decrease of the pyrogenic action of the same substances extracted from the tumor administered both cysteine and large dosis of MBAO was more remarkable, probably due to the protective action of cysteine for MBAO.